Studies on the Total Intake Simulant DMMPA,

Abstract

Dimethyl morpholinophosphoramidate (DMMPA) has been tested for suitability as a simulant for chemical agents in studying the effectiveness of chemical defence procedures. Results show that it is easily detected in urine after percutaneous, oral and intramuscular administration. The compound is shown to have very low toxicity when administered acutely in mice. Twenty-eight days of application to the skin of rats and rabbits produced no evidence of damage to skin. DMMPA is concluded to be useful and safe as a total intake simulant. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1977
Accession Number
ADA044065

Entities

People

  • P. A. Adie
  • W. Dorothy Mcnally

Organizations

  • Defence Research and Development Canada

Tags

DTIC Thesaurus Topics

  • Absorption
  • Abstracts
  • Accuracy
  • Chemical Warfare Agents
  • Chromatography
  • Detectors
  • Excretion
  • Flow Rate
  • Gas Chromatography
  • Intramuscular Injections
  • Propenes
  • Recovery
  • Security
  • Standards
  • Toxicity
  • Vapor Pressure
  • Volunteers

Readers

  • Analytical Mechanics
  • Toxicology/Environmental Toxicology