Chemical Analysis of Sulfones Used for the Treatment of Malaria.
Abstract
The purpose of these studies was to determine the contents of dapsone (4-4-diaminodiphenyl sulfone, DDS) and closely related trace chemical contaminants in pharmaceutical preparations of DDS employed previously for prophylaxis against malaria. The need for such information was based on the possibility that some contaminant in the DDS preparations used for mass prophylaxis of military personnel in Vietnam may have been responsible for the development of agranulocytosis in a number of subjects, with fatal outcome in eight persons.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1977
- Accession Number
- ADA044230
Entities
People
- John H. Peters
Organizations
- SRI International