Toxicology of DMMPA. Part II. The Effects of Chronic Application of DMMPA to Test Animals.
Abstract
The effects of chronic daily dosing of dimethyl morpholinophosphoramidate (DMMPA) have been assessed in rabbitss for dermal application and in rats for parenteral application. One hundred day application of DMMPA dermally to rabbits was without effect. One hundred day application to rats, both male and female, was without effect on breeding both in the incidence of pregnancies, number of pups per litter and the number of still-born. Three separate experiments are described in which male and female rats were dosed with DMMPA in periods from 100 to 240 days. Some thirty separate pathological screening tests were examined including nutritional, physiological, haematological, blood chemistry, tissue weight and water content procedures as well as macroscopic and microscopic pathology. Of these, only water intake, heart rate and lung damage were found to be affected. The highest dose of DMMPA having no effect on these latter parameters was 0.5 gm/kg/day. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1977
- Accession Number
- ADA044751
Entities
People
- I. W. Coleman
Organizations
- Defence Research and Development Canada