Adjuvant Effects on Immune Responses to Biologic Agents.
Abstract
This report describes the patterns of lymphocyte recirculation in normal animals, Radiokinetic and autoradiographic studies demonstrate that long-lived T and B cells selectively localize within organized lymphatic tissue as they recirculate between blood and lymph. Within the spleen, fluid flow through the open reticular meshwork permits both normal, enzyme-altered, and malignant lymphocytes to move across the splenic white pulp in a normal manner so that cellular traffic in this organ probably does not depend upon the same surface recognition mechanisms and cellular motility required for entry into peripheral lymph nodes. Recirculating lymphocytes move through all peripheral nodes and their apparent preferential accumulation within mesenteric nodes can be attributed to the large mass greater blood flow and higher background antigenic stimulation of these nodes rather than the presence of lymphocyte subpopulations which selectively 'home' into gut-associated lymphatic tissue. The correlation between histologic and quantitative measurement of cellur traffic into lymphatic tissues of young animals and the extent of development of high endothelial venules provides further support for the importance of cell surface recognition mechanisms in regulating lymphocyte recirculation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 20, 1977
- Accession Number
- ADA044839
Entities
People
- Norman D. Anderson
Organizations
- Johns Hopkins University