Evaluation of Pulmonary and Cardiovascular Effects of New Antimalarial and other Antiparasitic Compounds.
Abstract
Mefloquine methanesulfonate (WR-142,490.CH3SO3H), when infused at a dose -rate of 1 mg/kg/min for 20 minutes in the anesthetized dog, caused either little or no effect on the pulmonary and cardiovascular parameters measured during this drug infusion or in the following 3 hour observation period. However, dose-rates of 2 and 3 mg/kg/min of mefloquine MS for 20 minutes did produce pulmonary and cardiovascular changes. The respiratory parameters which were observed to change were: (1) tidal volume, which fell during the drug infusion but then returned to control values during the remaining portion of the observation period; (2) respiratory rate, which rose during the drug infusion but returned to control levels; (3) dynamic airways resistance, which fell during drug administration but then rose above control levels and (4) small gradual changes in blood pO2 and pCO2. High dose-rate infusion of mefloquine MS of 8 or 10 mg/kg/min, by the i.v. route, produced a dramatic drop in blood pressure, heart rate and tidal volume and equally marked elevations in respiratory rate and pulmonary artery pressure. Pulmonary wedge pressure was also slightly elevated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1976
- Accession Number
- ADA046318
Entities
People
- Clinton B. Nash
- Robert W. Caldwell
Organizations
- University of Tennessee