Synthetic Analogs of Phospholipid Metabolites as Antimalarials.
Abstract
Initial year's progress is described toward the synthesis of analogs of phospholipids and of their biosynthetic intermediates as possible antimalarials of a new type. Emphasis was placed on phosphonic and phosphinic acid analogs of lecithin, phosphatidic acid, cytidine diphosphate diglyceride, and cytidine diphosphate choline. Nine compounds were submitted of which one was a major target and three were secondary target compounds. None of the substances so far tested showed appreciable antimalarial activity. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 28, 1977
- Accession Number
- ADA046528
Entities
People
- Arthur F. Rosenthal