The Effects of Acute Alterations in Hemodynamics, Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa.
Abstract
Using a previously described model for acute gastric mucosal ulcerogenesis (Gastroent. 68:699, 1975), studies indicated that methylprednisolone significantly protects against acute lesion formation by enhancing mucosal blood flow; that, at constant concentration of bile acid, lesion formation is a linear function of the concentration of hydrogen ion; and that, under non-ischemic conditions, in addition to affection significant inhibition of histamine stimulated H+ secretion, metiamide produces a concomitant reduction in venous alkaline-tide. Finally, it was also shown that concomitant histamine infusion neither protects nor augments lesion formation under the experimental circumstances described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1977
- Accession Number
- ADA046615
Entities
People
- Wallace P. Ritchie Jr.
Organizations
- University of Virginia