Hydrolysis of Enkephalin by Cultured Human Endothelial Cells and by Purified Peptidyl Dipeptidase
Abstract
The experiments indicate that rapid inactivation of enkephalins may be due to at least two different enzymes present in tissues. A peptidyl dipeptidase which is a component of plasma membrane of various cells may degrade enkephalins by liberating a C-terminal dipeptide and an aminopeptidase in endothelial cells may cleave peptides, that they are taken up as blood flows past the endothelial surface, at the N-terminal end.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1977
- Accession Number
- ADA046969
Entities
People
- Alice R. Johnson
- Ervin G. Erdos
- Nit T. Boyden
Organizations
- University of Texas at Austin