Alterations in Tissue Metabolism (The Lung) with Injury and Shock.
Abstract
With circulatory failure in various organs, particularly the liver, kidney and muscle, the initial change is an alteration in the membrane of the cell with the decreased cell membrane potential and with an alteration in cation transport and in responsiveness to various hormonal substances. Sodium then tends to enter the cell, water also enters, potassium tends to leak out, Na(+) + K(+) -ATPase is activated, ATP is progressively used up, mitochondria are stimulated, cyclic AMP tends to decrease, further sodium gets into the cell and there is progressive cell swelling, there is mitochondrial swelling and the endoplasmic rectriculum swells. As this occurs, there seems to be alteration in the ability of insulin, glucagon and perhaps catecholamines and corticosteroids to exert their efforts upon the cell population. Metabolic capability further decreases, less ATP is produced, the glycolytic reactions may continue but oxidative metabolism is depressed, further deterioration occurs, and finally as an end stage result lysosomes leak and the cells are eventually destroyed. Toxic factors may then affect cell population in the same organ or elsewhere.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 15, 1975
- Accession Number
- ADA047443
Entities
People
- Arthur E. Baue
Organizations
- University of Washington