Chemotherapy of Leishmaniasis.
Abstract
During the period March 1976 - March 1977 progress has been reported in (1) cultivation of a number of species of Leishmania, and (2) strain maintenance utilizing the cryobank which now holds nearly 600 isolates at liquid nitrogen temperature. A comparative ultrastructual study of Noguchi-Adler bodies showed interesting external differences and intracellulor structural changes. Also, ultrastructural studies of L. hertigi have revealed paracrystalline arrays of ribosomelike particles, situated close to the karyosome. Considerable progress has been reported in the biochemical taxonomic studies of African Leishmania; L. donovani s.l., L. braziliensis, and L. hertigi. Other studies report on the interaction Leishmania and macrophages in vitro; immunological studies, including the effect of immunopotentiating and immunosuppressive drugs, and immunological status of laboratory workers; metabolic studies of amastigotes of Leishmania; and chemotherapy. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1977
- Accession Number
- ADA047617
Entities
People
- Wallace Peters
Organizations
- Liverpool School of Tropical Medicine