Alterations in Tissue Metabolism (The Lung) with Injury and Shock.
Abstract
The results indicate that the extent to which tissue ATP levels decreased during shock may be related to the metabolic activity of the organ or tissue. Associated with the decrease of tissue ATP levels was a decrease in tissue cyclic AMP levels. The results also indicate that the ability of tissue to regenerate ATP is markedly decreased during shock. Basal gluconeogenesis was unaltered during shock and steroids were found to be as effective in stimulating or inhibiting gluconeogenesis during hemorrhagic shock as they were under control conditions. Evidence is presented which indicates that ATP can cross the intact cell membrane. During severe hemorrhagic shock, there is insulin resistance at the tissue level. This resistance to insulin on glucose uptake can be overcome by treatment of animals in shock with ATP-MgCl2. Our results support the concept that inadequate shuttle enzymes is related to lactate production in the lung and that increased shuttle enzyme activity is associated with alloxan injury. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1976
- Accession Number
- ADA047710
Entities
People
- Arthur E. Baue
Organizations
- Yale University