Effect of Staphylococcal Enterotoxin B on Cardiorenal Functions and Survival in X-Irradiated Rhesus Macaques.
Abstract
Pretreatment of monkeys with nonlethal total-body x-irradiation (400 R) prolonged survival time from an average of 15 to 101 hours after intravenous (IV) inoculation of 50 micrograms/kg of staphylococcal enterotoxin B (SEB). Radiation exposure per se did not produce detectable cardiorenal changes. However, the longer survival after SEB challenge in x-irradiated monkeys was associated with improved cardiorenal functions when compared to nonirradiated monkeys given the same dose of SEB. Total-body radiation exposure 4 days prior to IV SEB inoculation prevented typical SEB-induced decreases (where measured at 5 hours) in cardiac output, stroke volume, concentration of solute-free water, clearance of para-amino-lippurate, osmolar clearance, and urine flow, as well as increases in total peripheral and renal resistance. A theory concerning the significance of radiation-induced leukopenia on modification of SEB-induced cardiorenal functions is postulated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 10, 1977
- Accession Number
- ADA047766
Entities
People
- C. T. Liu
- D. E. Hilmas
- M. J. Griffin
Organizations
- United States Army Medical Research Institute of Infectious Diseases