The Accuracy of Curve Fitting Procedures for the Determination of the Rate Constant for Reactivation of an Acylated Esterase,

Abstract

Curve fitting procedures were examined for determination of the three unknown parameters A, B and k in the equation y = A-Be(-kt). Six methods were evaluated: one based on the sum of differences, three based on the sum of squares, and two based on the sum of squares for the equation in a linear form. It was concluded that no method was satisfactory. Even when an apparently accurate estimate of the rate constant k was obtained, it was accompanied by wide confidence limits. If possible, the constant A should be determined independently; satisfactory results can then be obtained. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1977
Accession Number
ADA048027

Entities

People

  • H. A. Kellock
  • R. M. Dawson
  • W. M. Harper

Organizations

  • Defence Science and Technology Group

Tags

Communities of Interest

  • Weapons Technologies

DTIC Thesaurus Topics

  • Accuracy
  • Australia
  • Chemistry
  • Computer Programs
  • Computers
  • Confidence Limits
  • Curve Fitting
  • Data Science
  • Data Sets
  • Department Of Defense
  • Engineering
  • Enzyme Kinetics
  • Equations
  • Information Science
  • Materials
  • Reliability
  • Standards

Fields of Study

  • Chemistry

Readers

  • Regression Analysis.