Immunological Studies on Herion Addiction.

Abstract

Hemagglutination-inhibition (HI) procedures for the detection of morphine, methadone and barbiturates have been devised, developed and validated to the point of their adoption by diagnostic laboratories, and the necessary reagents have become available through commercial sources. The HI test for the detection of the major cocaine metabolites suffers from interference by unidentified substances found in some human urine specimens. After appropriate adjustment for this interference the test detects cocaine metabolites for about 4 days after last use of the drug. HI tests for detection of amphetamine and LSD have yet to be completely developed. The application of serological methods for the study of pharmacokinetics has been critically examined and the results have been submitted for publication. Finally, the generation of specific antibodies in response to morphine administration has been verified, but the biological significance of this phenomenon remains in question. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1975
Accession Number
ADA048215

Entities

People

  • Chi-tan Liu
  • Frank L. Adler

Organizations

  • Public Health Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Addiction
  • Antibodies
  • Demographic Cohorts
  • Detection
  • Drug Abuse
  • Field Conditions
  • Health
  • Inhibition
  • Metabolites
  • Morphine
  • New York
  • Public Health
  • Three Dimensional

Fields of Study

  • Biology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Immunology
  • Systems Analysis and Design