Vaccine Development in Trypanosomiasis.
Abstract
This program sought to develop an effective, practical vaccine against African trypanosomiasis, useful to both military and civilian agencies. Related benefits include acquisition of knowledge pertaining to trypanosome immunity, host response and pathology of infection. Experiments conducted at WRAIR and in Kenya have demonstrated that experimental animals can be successfully immunized with irradiated trypanosomes. Rodents, cattle and monkeys can be rendered completely resistant to a challenging infection of T. rhodesiense. Partial immunity has been achieved against T. congolense. Continuing studies in Lambwe Valley, Western Kenya, show that 18 of 31 and 21 of 29 isolates from humans over a 7-year period are neutralized by two antisera, respectively. Five of 27 isolates from bovines also were neutralized by one antiserum. This indicates that stability of antigenic types has persisted throughout this period and that cattle are a reservoir host in the valley. Complete resistence to T. congolense has been achieved by repeated infection and cure. This immunity appears to be maintained after both syringe and tsetse fly challenge.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1977
- Accession Number
- ADA049582
Entities
People
- B. T. Wellde
- I. Muriithi
- R. M. Kovatch
- W. T. Hockmeyer