Effects of Local Anesthesia on Gingival cAMP Levels.
Abstract
The basic levels of cAMP in the attached gingiva of Rhesus monkeys and the changes in tissue cAMP levels produced by infiltration anesthesia with Lidocaine and Lidocaine containing 1:100,000 epinephrine was studied. The basal level of cAMP in uninjected monkey gingiva ranged from 12-20 picomoles cAMP/mg of gingival protein. This level was 75 times greater than the cAMP content of monkey blood plasma. Infiltration of the attached gingiva with saline or plain Lidocaine for 5 min. did not produce any significant changes in tissue cAMP levels. Infiltration of the gingiva with Lidocaine containing 1:100,000 epinephrine, on the other hand, caused a very marked increase in tissue cAMP levels. Thirty seconds after infiltration with Lidocaine with 1:100,000 ephinephrine there was a 150% increase in cAMP content of the anesthetized tissue versus the uninjected control tissues. The maximal increase in tissue cAMP levels was observed 5 min. after infiltration when the cAMP content of the gingiva was 1000-1100% above the control level. It is proposed that regulation of tissue cAMP levels by epinephrine or other agents may prove of therapeutic usefulness in regulating inflammation and healing of tissues after surgery or other trauma. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 02, 1978
- Accession Number
- ADA049633
Entities
People
- Dorothy Chandler
- George C. Kramer
- John A. Stow
- Marvin F. Grower
Organizations
- United States Army Institute of Surgical Research