'Plasmodium berghei berghei': Irradiated Sporozoites of the ANKA Strain as Immunizing Antigens in Mice

Abstract

Mice were protected against challenge with infective sporozoites following immunization with X-ray irradiated sporozoites. The immunity lasted at least 8 weeks. Mice immune against sporozoite challenge remained fully susceptible to challenge with erythrocytic stages. Immunization of mice with extracts of mosquito thorax failed to protect them, indicating that mosquito antigens were not directly responsible for the immunity observed in the basic experiments.

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Document Details

Document Type
Technical Report
Publication Date
Jul 21, 1975
Accession Number
ADA049670

Entities

People

  • Cloyce P. Strome
  • Fred Mitchell
  • Richard L. Beaudoin
  • Theodore A. Tubergen

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Animals
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cell Physiological Processes
  • Cells
  • Experimental Design
  • Immunity
  • Immunization
  • Infection
  • Malaria
  • Navy
  • Parasites
  • Vaccines
  • Wound Infections
  • X Rays

Fields of Study

  • Biology
  • Medicine

Readers

  • Exercise and Sports Science.
  • Immunology
  • Parasitology and Pharmacology of Malaria.