The Ganglionic Blocking Properties of the Cholinesterase Reactivator HS-6.
Abstract
Following I.V. administration of 30 mg/kg of the cholinesterase reactivator HS-6, blood pressure fell (up to 50 mm/Hg) and maximal blood levels of HS-6 reached 242 micrograms/ml. HS-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation. Doses of HS-6 below those tested therapeutically against soman in different animal species (3.59-10.77mg/kg) progressively blocked the ganglion stimulating effects of nicotine and dimethylphenylpiperazinium but not those following adrenaline, a pattern similar to that produced by hexamethonium but only 1/84 as potent. HS-6, like hexamethonium and mecamylamine, progressively blocked the contraction of the nictitating membrane of the cat resulting from pre-ganglionic stimulation. The results indicate that HS-6 possesses ganglion blocking properties at doses likely to have any any value therapeutically in soman poisoning. The ganglion blocking properties of the drug may be a factor in the beneficial effects of HS-6. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1978
- Accession Number
- ADA050202
Entities
People
- D. H. Mckay
- P. M. Lundy
Organizations
- Defence Research and Development Canada