Morphine Depression of Ventilatory Response to Hypoxia, and Reversal by Naloxone,

Abstract

Ventilatory response to 'isocapnic' hypoxia was measured in awake beagle dogs prior to and following administration of intravenous morphine sulfate, 0.6 mg/kg. Hypoxic ventilation was depressed within 30 minutes, was maximally depressed at one to two hours, and remained depressed for at least six to seven hours following the administration of morphine. Naloxone, 0.4 mg IV, completely reversed the morphine depression of the ventilatory response to hypoxia, but only transiently; 30 to 45 minutes after naloxone reversal, the ventilatory respone to hypoxia was again significantly depressed. Naloxone alone demonstrated mild agonist properties on the ventilatory response to hypoxia, but the effect varied among the dogs. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1977
Accession Number
ADA050538

Entities

People

  • George Volpe
  • Nancy Mcgavock
  • Richard B. Weiskopf
  • Vincent Forte

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Anesthesiology
  • Animals
  • Blood Flow
  • Carbon Dioxide
  • Depression
  • Digital Computers
  • High Altitude
  • Laboratory Animals
  • Medical Personnel
  • Morphine
  • Narcotics
  • Pharmacology
  • Physiology
  • Respiration
  • Security
  • Ventilation

Fields of Study

  • Biology
  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology