Behavioral Effects of Massive Transfusion with Cell-Free Resuscitating Solutions,

Abstract

Fixed ratio (FR) and DRL (differential reinforcement of low response rates) operant behavior of rats was examined following 65 percent exchange transfusion with bovine serum albumin (BSA), stroma-free hemoglobin (SFH), or a mixture (MIX) of these materials. Transient performance decrements were observed following transfusion with each solution. FR response rates of transfused animals were significantly depressed in comparison to surgical controls 24 hrs after exchange transfusion, but differences between transfused groups were not significant. There were no significant differences in FR response rates between the surgical control, hemoglobin-albumin, and albumin groups after the first daily test session. Response rates of the SFH group remained significantly lower in comparison to all other groups through the fourth day of testing. Transfusion related changes in DRL performance were similar to those observed with the FR task. Behavioral recovery appeared to be complete in all animals by the second week of testing.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1978
Accession Number
ADA050832

Entities

People

  • Frank Devenuto
  • Gail E. Esgandarian
  • Paul W. Mellick
  • Peter A. O'mara
  • Robert A. Patterson

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Biological Sciences
  • Blood
  • Blood Transfusions
  • Bone Marrow
  • Cardiovascular System
  • Cells
  • Chemistry
  • Hemoglobin
  • Lymph Nodes
  • Lymphatic System
  • Materials
  • Nervous System
  • New York
  • Observation
  • Surgery
  • Veins

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.