Evaluation of a Nuclease-Resistant Derivative of Poly(I) Poly(C) (Poly(ICLC)) as a Radioprotective Agent 1, 2.

Abstract

The synthetic double-stranded ribonucleic acid, polyriboinosinic acid polyribocytidylic acid (poly(I) poly(C)) is an interferon inducer, has antiviral and antitumor properties, and has been shown to be radioprotective in rodents. The observation that the radioprotective action of poly(I) poly(C), as well as certain endotoxins and chemicals, may be associated with their ability to induce interferon, has also stimulated interest in the possible radioprotective action of interferon itself.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1978
Accession Number
ADA051580

Entities

People

  • Duane E. Hilmas
  • Eduard Lvovsky
  • Glen A. Higbee
  • Hilton B. Levy
  • Wallace B. Baze

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Base Lines
  • Biological Factors
  • Blood
  • Blood Cells
  • Cells
  • Chemistry
  • Chemotherapeutic Agents
  • Diseases And Disorders
  • Factor Analysis
  • Infectious Diseases
  • Interferon
  • Intramuscular Injections
  • Lymphatic System
  • Lymphocytes
  • Radioprotective Agents
  • Ribonucleic Acids

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Virology (or Medical Virology).