Fixed Ratio Performance in Rats Following Massive Transfusion with Cell-Free Resuscitating Solutions,
Abstract
Rats were trained to perform a fixed ratio (FR) bar press task in order to obtain food reinforcement. FR operant behavior was then examined daily following 65 percent exchange transfusion with bovine serum albumin (BSA), stroma-free hemoglobin (SFH) or a mixture of those materials. A fourth group of rats (controls) was subjected to identical surgical and anesthetic procedures, but was not transfused. Average FR response rates of all transfused groups were significantly depressed in comparison to surgical controls 24 hr after exchange transfusion. The degree of this initial response depression was inversely related to baseline FR response rates. Histograms of interresponse times (IRTs) were also derived. Following exchange transfusion, there were increases in the relative proportions of long IRTs and a slowing of IRTs representing fast response sequences. Changes in FR response rates and in IRT distributions also depended upon the type of transfusion solution employed. Rats transfused with MIX were least affected although the differences between this group and the BSA group were not significant. Rats transfused with SFH showed the greatest initial response decrement. The recovery of the SFH group was also significantly longer than those of the control and MIX groups. There were no significant between-group differences in FR performance by the second week of recovery. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1978
- Accession Number
- ADA051765
Entities
People
- Frank Devenuto
- Gail Esgandarian
- Peter A. O'mara