Chemotherapy of 'Trypanosoma rhodesiense'.
Abstract
The test system described herein was developed specifically to evaluate the trypanosomicidal activity of large numbers of candidate compounds. Based on blood-induced Trypanosoma rhodesiense infections in mice, it performs as a primary screen or as a secondary screen and confirmatory test and gives precise quantitative evaluations of chemical compounds that demonstrate potentially useful therapeutic and/or prophylactic activity in T. rhodesiense infections. Consequently, it is also a helpful guideline in the synthesis of new active agents. These agents include: (1) chemicals structurally related to compounds of known value in the treatment or prevention of T. rhodesiense infections; (2) chemicals structurally unrelated to compounds of known value in the treatment or prevention of T. rhodesiense infections and; (3) structural analogues of compounds that have demonstrated activity in our screening procedure and represent novel chemical groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1974
- Accession Number
- ADA052299
Entities
People
- Dora S. Rane
Organizations
- University of Miami