Oxazinediones and Related Compounds as Antimalarial Agents.

Abstract

Objective- To develop new chemical agents for the treatment of malaria and related parasitic diseases by preparing samples of new organic compounds for testing against murine malaria. Rationale- Because simple derivatives of compounds containing the oxazinedione ring system were known to exhibit inhibitory activity in E. coli. and other microorganisms, it was hoped that a systematically prepared group of derivatives of oxazinediones would include compounds of activity against Plasmodia.

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Document Details

Document Type
Technical Report
Publication Date
Apr 04, 1978
Accession Number
ADA052694

Entities

People

  • Stephen S. Washburne

Organizations

  • Temple University

Tags

DTIC Thesaurus Topics

  • Anhydrides
  • Chemical Synthesis
  • Chemistry
  • Hydroxides
  • Mass Spectra
  • Materials
  • Medical Personnel
  • Organic Chemistry
  • Organic Compounds
  • Parasitic Diseases
  • Plastic Explosives
  • Sodium Compounds
  • Sodium Hydroxide
  • Spectra
  • Test Methods

Fields of Study

  • Medicine

Readers

  • Microbial Pathology
  • Parasitology and Pharmacology of Malaria.