Suppression of PHA-Stimulated Lymphocyte Transformation in Cynomolgus Monkeys Following Infection with Coxiella Burnetii.
Abstract
Phytohemagglutin-induced blastogenesis of peripheral blood lymphocytes from cynomolgus monkeys infected with Coxiella burnetii was suppressed between 14 and 28 days after infection. Lymphocytes became responsive to PHA again on day 35 with an increase in stimulation index when cultured with specific antigens. In contrast, production of specific humoral antibodies was not diminished during the acute and early convalescent stages of infection. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 11, 1978
- Accession Number
- ADA054197
Entities
People
- J. C. Gonder
- R. A. Kishimoto
Organizations
- United States Army Medical Research Institute of Infectious Diseases