New Approaches to Chemotherapy of Viral Diseases.
Abstract
Two aspects of previously established but insufficiently examined actions of SM-1213 were investigated during the contract period (six months): (a) the interaction of SM-1213 with immunomodulatory stressors; and (b) the effects of SM-1213 on macrophage function. Psychosocial stress induced by housing female mice in pairs and 'infection' stress generated with a subclinical herpes simplex type 1 viral infection were examined for their effects on immediate and delayed type hypersensitivity responses to RBC antigens in the presence and absence of drug treatment (80 mg/kg/day SM-1213) administered ad libitum beginning on Day 6 following immunization. Both classes of stress produced immunosuppression which was restored by treatment with drug; herpes infection lowered antibody levels that were restored by treatment. As expected, high and low psychosocial stress inputs generated animals with significantly different adrenal weights, while SM-1213 treatment tended to prevent the shift in weight produced by change in environment. In mouse macrophages infected by herpes simplex type 2 virus, studies employing fluorescent antibody techniques showed drug to significantly reduce the number of infected macrophages.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 19, 1978
- Accession Number
- ADA054345
Entities
People
- Paul Gordon
Organizations
- Stritch School of Medicine