Synergism between Oncogenic Human Herpes Viruses and Carcinogenic Chemical

Abstract

Six chemicals were tested for synergism in promoting in vitro oncogenic transformation of Swiss mouse 3T3 cells by herpes simplex type 2 virus (HSV-2). The test chemicals were N,Nitrosodimethylamine, 1,2-dimethylhydrazine, hydrazine, methylhydrazine, 1,1-dimethylhydrazine, and N-phenyl-alpha- naphthylamine. 1,2-dimethylhydrazine (symmetrical dimethylhydrazine, SDMH) enhanced the level of oncogenic transformation approximately two-fold. None of the other test chemicals enhanced HSV-2 transformation at the concentrations tested. The significance of these data is somewhat uncertain at this point, but certainly follow-up studies should be conducted to confirm the apparent enhancement of viral transformation by SDMH.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1978
Accession Number
ADA054595

Entities

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  • F. B. Johnson

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  • Air Force Research Laboratory

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  • Biomedical

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  • Air Force
  • Biomedical Research
  • Diseases And Disorders
  • Fibroblasts
  • Government Procurement
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  • Hydrazines
  • Infection
  • Materials
  • Microbiology
  • Security
  • Synergism
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  • Toxic Hazards
  • Universities
  • Virginia

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  • Infectious Disease/Epidemiology
  • Toxicology/Environmental Toxicology
  • Underwater engineering and Marine Technology.