Experimental Q Fever Infection in Congenitally Athymic Nude Mice.
Abstract
Congenitally athymic nude (nu/nu) mice and their phenotypically normal (nu/+) euthymic littermates were exposed to Coxiella burnetii administered as small-aerosol particles. Following challenge, both strains of mice became infected, as characterized by rickettsemia, viable rickettsiae in the spleen, and serologic conversion. The major difference noted was that euthymic animals had cleared rickettsiae from peripheral circulation and the spleen within 14 days. In contrast, rickettsiae were detected and isolated from spleen and blood of athymic mice through 60 days. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1978
- Accession Number
- ADA054620
Entities
People
- E. W. Larson
- H. Rozmiarek
- R. A. Kishimoto
Organizations
- United States Army Medical Research Institute of Infectious Diseases