Studies of Metabolism, Function and Mechanism of Destruction of Red Cells.
Abstract
The effect of contrast materials on red cell membrane potential and on the pH of plasma and red cells have been studied. These studies indicate that contrast materials alter the red cell membrane potential and in so doing, cause a redistribution of protons such that plasma is acidified. This effect occurs in vivo as well as in vitro. However, the nature of the contrast material, the site of injection, and the transit time of the contrast material are important factors in determining the pH of blood in a regional capillary circulation. The writers examined the role of oxygen hemoglobin affinity on oxygen delivery in patients with cardiac decompensation. A decrease in oxygen affinity occurs as arterial oxygen flow rate falls and this minimizes the reduction in venous partial pressure of O2 needed to maintain oxygen consumption. They established a model for the study of oxygen transport using the gracillis muscle of the dog. Preliminary studies indicate that alkalosis does not impair resting or exercising oxygen consumption if flow rate is normal. If flow is reduced, alkalosis may impair oxygen consumption during exercise.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1978
- Accession Number
- ADA054652
Entities
People
- Jules Cohen
- Marshall A. Lichtman
Organizations
- University of Rochester