The Effects of Acute Alterations in Hemodynamics, Oxygen Availability, and Acid-Base Balance in the Permeability of the Gastric Mucosa.
Abstract
Using a previously described model for acute gastric mucosal ulcerogenesis (Gastroent.68:699, 1975), studies carried out in this laboratory indicate that acute gastric mucosal ulcerogenesis may be a consequence of uncompensated tissue acidosis; that the topical application of 16,16 DM PGE2 significantly ameliorates bile acid-ischemia induced acute mucosal lesion formation; and that intravenous metiamide is cyto-protective under the same circumstances, perhaps as a consequence of its ability to decrease the apparent permeability of the gastric mucosa to cations.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 24, 1978
- Accession Number
- ADA055110
Entities
People
- Wallace P. Ritchie Jr.
Organizations
- University of Virginia