Research on Immunization Against African Sleeping Sickness,
Abstract
It has been demonstrated that the antigenic character of the parasite population of T. rhodesiense from an endemic area was composed of perhaps as few as one serodeme which was antigenically stable over an 8-year period. It was also found that immunity can be induced to blood and tsetse fly (metacyclic) forms by exposure of experimental animals to a broad spectrum of antigenic variants of the same serodeme. The sterile immunity described in these studies was long lasting. It is believed that these findings enhance the likelihood of immunologic control of trypanosomiasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1978
- Accession Number
- ADA056458
Entities
People
- Bruce T. Wellde
- Robert M. Kovatch
- Wayne T. Hockmeyer