Morphologic and Biochemical Effects of Oxygen Toxicity.
Abstract
Morphologic and biochemical studies dealing with effects of high O2 concentrations were made on a wide range of cell types including protozoa, mammalian cell lines, lung cells and marine invertebrate and amphibian eggs. Studies were aimed at evaluating effects of O2 on proteolysis of cells, on mitoses, on DNA, RNA and protein synthesis, on the etiology of alveolar lining cell injury, and on the development of O2 tolerance in rats. Peripheral areas related to these studies dealt with the demonstration of different subgroups of the same family of some acid hydrolases and effects of O2 on the two pathways of serotonin metabolism. Ultrastructural studies stressed the conformational changes of mitochondria in type 2 cells of tolerant rats and sequence of O2 induced injury at the level of terminal airway. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1978
- Accession Number
- ADA056778
Entities
People
- Murray Wittner
- Robert M. Rosenbaum
Organizations
- Albert Einstein College of Medicine