'Escherichia coli' Shock Following Corticosteroid Treatment: A Pathologic Study in Baboons.
Abstract
The purpose of this study was to determine if corticosteroids would prevent the development of the pathologic lesions of septic shock in baboons treated with live E. coli organisms during a 24-hour study period. Pathologic changes were defined for multiple organs and compared to the lesions previously described in shock in humans. Eleven awake baboons were infused with comparable doses of live E. coli organisms during a 5-hour period with one member of each pair receiving methylprednisolone. One additional animal received saline in place of organisms and served as a control. Results of this study would indicate that adrenal corticosteroids do not prevent and/or decrease the severity of any of the morphologic lesions in the baboon subjected to low or high doses of E. coli organisms. The pathologic changes induced by live E. coli organisms in the baboon include fibrin thrombi, edema and/or hemorrhage, and necrosis of multiple organ systems. The liver, adrenal, and kidney show striking pathologic changes whereas the gastrointestinal tract shows no significant pathologic alteration. This morphologic study demonstrates that the shock lesions of the subhuman primate and human are remarkably similar.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 12, 1978
- Accession Number
- ADA057458
Entities
People
- B. A. Benjamin
- B. K. Beller
- J. J. Coalson
- Linda T. Archer
- R. H. Spaet
Organizations
- University of Oklahoma Health Sciences Center