Treatment of Trauma and Shock with Use of Red Blood Cells that Enhance Oxygen Delivery to Tissues: Effect of Red Blood Cells with Normal, Decreased, or Increased Affinity for Oxygen on Normal and Ischemic Cardiac Function.

Abstract

AN experimental model of shock and trauma was developed in isolated rabbit hearts subjected to low levels of coronary arterial flow (ischemia). A high level of glucose and insulin was beneficial to the heart subjected to ischemia; equiosmolar mannitol had no effect. A blood-perfused rabbit heart was developed using outdated human red blood cells. The performance data of the blood-perfused heart under well-oxygenated conditions is reported. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1978
Accession Number
ADA057763

Entities

People

  • Carl S. Apstein

Organizations

  • Boston University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemistry
  • Electron Microscopy
  • Flow Rate
  • Frequency
  • Heart
  • Heart Rate
  • Metabolism
  • Military Research
  • Recording Systems

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology