Investigation of N,N-Diethyl-M-Toluamide(M-Det) for Dominant Lethal Effects in the Mouse.

Abstract

A single dose of N,N-diethyl-m-toluamide (m-Det) in corn oil was administered to male mice by gavage in a dominant lethal assay to evaluate its potential mutagenicity in male germ cells. The compound did not induce a positive mutagenic response during an 8-week mating period in which each of 10 males was cohoused weekly with 3 untreated virgin females, although there was a slight, but statistically insignificant reduction in the total number of fetal implants. This reduction was probably not genetic in origin. Triethylenemelamine (TEM), which served as the positive control, induced a dominant lethal response during weeks 1, 2, 3 and 6 of mating. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1977
Accession Number
ADA058414

Entities

People

  • Kipling C. Swentzel

Organizations

  • United States Army Medical Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Environmental Protection
  • Fertility
  • Germ Cells
  • Health Services
  • Insect Repellents
  • Laboratory Animals
  • New York
  • Oils
  • Pest Control
  • Pesticides
  • Plant Oils
  • Pregnancy
  • Test And Evaluation
  • Toxicity
  • United States

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology