Reactions of Methamidophos with Mammalian Cholinesterase,
Abstract
The lethality of methamidophos, a phosphoramidothioate, to rats (i.p. LD50, 15 mg/kg), is similar to that of such potent organophosphate compounds as parathion and paraoxon. Certain distinctive features of its chemical structure, and reported failure of cholinesterase inhibited with methamiodophos to reactivate spontaneously in insects, prompted this study of its reactions with mammalian cholinesterase to determine if the treatment of poisoning requires modification. Atropine (10 mg/kg) or pralidoxime (60 mg/kg) afforded significant protection against lethality from methamidophos (LD50's, 60 + or - 0.4 and 52 + or - 4.9 mg/kg, respectively). Partial spontaneous recovery of inhibited cholinesterase activity was observed. However, a single dose of pralidoxime, given essentially simultaneously with methamidophos, did not hasten the recovery of cholinesterase activity. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1978
- Accession Number
- ADA058683
Entities
People
- Casey P. Robinson
- Charles R. Crane
- Donald Beiergrohslein
- Paul W. Smith
Organizations
- Federal Aviation Administration