Myocardial Function in Endotoxin Shock.
Abstract
Coronary hypoperfusion and depressed responses to beta adrenergic stimuli are prime factors in the elicitation of cardiac dysfunction. Intracardiac disturbances perform a major role but their causes are obscure. Associated together in this latter category are the development of edema in the myocardium occurring in both the contractile elements and mitochondria; ionic imbalances of potassium and probably calcium; and elevations of left ventricular end diastolic pressure and depressions of negative dP/dt sub max, cardiac power and efficiency. The interactions and additive effects of these factors are responsible for the development of myocardial dysfunction in endotoxin shock. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 28, 1978
- Accession Number
- ADA061525
Entities
People
- Lerner B. Hinshaw
Organizations
- University of Oklahoma Health Sciences Center