The Synergistic Effect of Ultrasound and Ionizing Radiation on Human Lymphocytes.
Abstract
Lymphocytes in human peripheral blood were exposed to various combinations and sequences of heat, ultrasound and/or ionizing radiation and their chromosomes analyzed for gross chromosomal aberrations. The combined use of ultrasound and ionizing radiation showed a statistically significant increase in exchange aberrations for the simultaneous ultrasound (3.0 W/sq cm, CW, 1.1 MHz) and ionizing radiation (300 and 100 rads, Co-60, 120 rads/min) exposures. Ultrasound used before or after irradiation caused no aberrations and extending the time of ultrasound exposure after irradiation had no effect over that of the ultrasound only during the radiation exposure. The combined use of 43 C heat (same temperature as that induced by 3.0 W/sq cm, CW, 1.1 MHz ultrasound) and ionizing radiation showed basically the same significant results as the combined ultrasound and ionizing radiation exposures. In addition, the combined use of heat at various temperatures (24 C thru 43 C) and ionizing radiation showed that all chromosome aberration types and the number of aberrant metaphase figures increased with increasing temperature. A statistical comparison of the heat plus ionizing radiation and the ultrasound plus ionizing radiation exposures showed no statistically significant difference between heat or ultrasound for any type aberration. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1978
- Accession Number
- ADA061537
Entities
People
- John G. Burr
Organizations
- Air Force Institute of Technology