The Hypermetabolism of Total Acquired Lipodystrophic Diabetes. Effect of Diet on Thyroid Hormone Concentrations and Metabolic Rates,
Abstract
The spontaneous hypermetabolism of total acquired lipodystrophy is related to dietary intake and thyroid hormone metabolism. The elevated metabolic rate has been shown to fall with fasting and thyroidectomy and is restroed with refeeding and physiologic replacement of thyroid hormones, respectively. Similar associations have been shown in normal volunteers in whom starvation is associated with a decrease in metabolic rate (MR) and 3,3',5-triiodothyronine (T3) concentration and a rise in 3,3',5-triiodothyronine (rT3) concentration. Thyroxine(T4) concentrations also varied with caloric intake but this was mostly due to changes in thyroid binding protein concentration or affinity. rT3 concentrations were relatively unchanged throughout the study period. Metabolic rates in the control subject rose only with protein supplementation and fell during the three-day fast. Of the three thyroid hormones measured, only T3 varied with caloric intake. A crude but more accurate method of expressing metabolic rate in lipodystrophy may be as Watt/kg estimated lean body mass. On this basis, the lipodystrophic subject has a more normal metabolic rate when she consumes less food. The elevation in metabolic rate seen with greater caloric intake may be a response to the inability to store excess calories as fat. It is concluded that the association between total caloric intake and metabolic rate in lipodystrophy may represent a form of dietary-induced thermogenesis. The role of thyroid hormones and in particular T3 in this process is unclear. However, physiologic fluctuations in T3 concentrations in response to the content and composition of the diet may be one of several mechanisms that regulate metabolic rate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 05, 1978
- Accession Number
- ADA062927
Entities
People
- David C. Robbins
- Edward S. Horton
- Elliot Danforth Jr.
- Ralph F. Goldman
- Richard L. Burse
Organizations
- United States Army Research Institute of Environmental Medicine