Altered Zinc Homeostasis and Hepatic Accumulation of Metallothionein in Indomethacin-Induced Enteropathy.
Abstract
Altered zinc homeostasis is one of several metabolic sequelae of inflammation wherein zinc is redistributed to the liver from endogenous sources such as plasma. Studies were performed in rats to determine the effect(s) of indomethacin, a potent anti-inflammatory and ulcerogenic agent, on zinc metabolism. A single sc or ip dose of indomethacin given to fed rats in amounts between 1-10 mg/100 g body weight induced, by 24 hr, profound hypozincemia, enhanced intestinal absorption of zinc, induction of hepatic metallothionein synthesis, and gastrointestinal lesions. These responses were significantly muted when the drug was administered to fasted rats. The effects of indomethacin on zinc homeostasis appears to be related to drug-induced enteropathy. Furthermore, results provide evidence that hepatic metallothionein functions, at least in part, to sequester zinc in pathophysiologic conditions. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 20, 1978
- Accession Number
- ADA062984
Entities
People
- E. C. Hauer
- G. L. Knutsen
- P. Z. Sobocinski
- W. J. Canterbury Jr.
Organizations
- United States Army Medical Research Institute of Infectious Diseases