Immunoglobulins in Periodontal Tissues. III. Concentrations of Immunoglobulins in Dilantin Induced and Idiopathic Gingival Hyperplastic Tissues.

Abstract

Diphenylhydantoin sodium (Dilantin), prescribed for extended periods of time for the treatment of epilepsy, frequently produces side effects and idiosyncratic reactions. Nystagmus, blurred vision, slurred speech, and ataxia are dose related side effects which usually subside following drug withdrawal. Skin rashes accompanying manifestations of allergy to Dilantin have been reported in 5-10% of patients. Depression of one or more parameters of the cellular and/or humoral immune response has been described as occurring in 60%. Rarer reactions such as aplastic anemia, systemic lupus erythematosus, erythema multiforme, and Stevens-Johnson syndrome also occur. Fibrous hyperplasia of the gingiva occurs in 57% of patients on Dilantin therapy who are less than 26 years of age, but only in 21% of those who are older.

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Document Details

Document Type
Technical Report
Publication Date
Dec 12, 1978
Accession Number
ADA063169

Entities

People

  • Arthur Gross
  • Jean A. Setterstrom
  • R. F. Godat
  • Sandra M. D'alessandro

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Anticonvulsants
  • Collagen
  • Connective Tissue
  • Diseases And Disorders
  • Drug Therapy
  • Drug Withdrawal
  • Hematologic Diseases
  • Hyperplasia
  • Materials
  • Mouth Diseases
  • Security
  • Skin Diseases
  • Statistical Analysis
  • Teeth
  • Therapy
  • Tissues

Fields of Study

  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Toxicology/Environmental Toxicology