Evaluation of the Occupational Health Hazards of Nitroglycerin Using Mammalian Models
Abstract
A system was designed and constructed to allow monitoring of blood flow by the use of Doppler flow probes. The Doppler signals are transmitted via an implanted FM transmitter to an external receiver, where the signal is processed and transformed to calibrated flow on a strip-chart recorder. This technique was used to measure the effect of inhaled or percutaneously administered nitroglycerin on coronary blood flow in dogs. The results of the preliminary inhalation experiments indicate that the technique is valid for investigating whether nitroglycerin causes increased coronary artery blood flow and whether compensatory or reflex vasoconstriction occurs upon withdrawal. Both dogs exposed by inhalation seemed to demonstrate these phenomena slightly.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 25, 1977
- Accession Number
- ADA063717
Entities
People
- James V. Dilley
Organizations
- SRI International