Mutagen and Oncogen Study on JP-8

Abstract

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. The test compound, JP-8 Tanic F-3, produced a moderate increase in unscheduled DNA synthesis in WI- 38 cells. These data suggest that the material could interact with DNA producting nonspecific lesions. No evidence for mutagenicity was evident in the test battery and the indications for mutagenic and carcinogenic potential for this compound are minimal at best. There is no suggestion of significant genetic risk associated with this material.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1978
Accession Number
ADA064948

Entities

People

  • Dale W. Matheson
  • David Brusick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Husbandry
  • Biomedical Research
  • Cells
  • Computer Programs
  • Computers
  • Data Analysis
  • Databases
  • Experimental Design
  • Germ Cells
  • Governments
  • Information Science
  • Materials
  • Measurement
  • Physiological Effects
  • Range Finding
  • Regression Analysis
  • Toxicity

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology