Mutagen and Oncogen Study on Triaminoguanidine Nitrate

Abstract

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. Triaminoguanidine nitrate (TAGN) was mutagenic and produced DNA damage in the in vitro assays. The response was obtained without the presence of an in vitro activation system, indicating that the TAGN molecule has genetic activity. No significant induction of dominant lethal effects was observed in either mice or rats. TAGN should be considered a suspect compound regarding mutagenic and carcinogenic potential. The combined positive results from all in vitro assays indicate a high level of probability for carcinogenic activity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1978
Accession Number
ADA064950

Entities

People

  • Dale W. Matheson
  • David Brusick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Husbandry
  • Biomedical Research
  • Cells
  • Computer Programs
  • Computers
  • Data Analysis
  • Databases
  • Experimental Design
  • Germ Cells
  • Governments
  • Information Science
  • Materials
  • Measurement
  • Microsomes
  • Molecules
  • Regression Analysis
  • Toxicity

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology