Mutagen and Oncogen Study on JP-4

Abstract

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. JP-4 was shown to induce nonspecific DNA damage in WI-38 cells and possibly preimplantation loss in rats. All other data from the test battery were negative. These results are not strong indications of human risk and could be considered as representing minimal genetic toxicity. Neither the unscheduled DNA synthesis or preimplantation loss are conclusive indicators of mutation. Their implications for potential carcinogenesis must also be considered weak in light of the majority of negative test data.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1978
Accession Number
ADA064952

Entities

People

  • Dale W. Matheson
  • David Brusick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Husbandry
  • Biomedical Research
  • Cells
  • Computer Programs
  • Computers
  • Data Analysis
  • Databases
  • Experimental Design
  • Germ Cells
  • Governments
  • Information Science
  • Materials
  • Measurement
  • Physiological Effects
  • Regression Analysis
  • Test And Evaluation
  • Toxicity

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Neuroscience
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology