Myocardial Effects of Shock.
Abstract
Background material for the original proposal indicated that one of the pathogenic considerations in shock was a specific humoral factor responsible for myocardial depression. This myocardial depression factor (MDH) was found to originate in ischemic gut; consequently the project focused upon the relative relationship between ischemic intestine and myocardial depressant activity. Because of difficulty in quantitating the degree of intestinal ischemia, its physiological significance and the production of the systemic effect, a series of studies were conducted. These documented: (a) significant impairment in bidirectional flow of fluid and electrolyte abnormalities in the presence of intestinal ischemia; (b) although autoregulation and autoregulatory escape could be well documented even in conditions of low pressure and after drug manipulation, these normal physiologic phenomena did not appear to be maintained when intestinal ischemia was extensive; (c) by the use of the tetrazolium assay for describing the degree of disruption and monitoring of mucosal and serosal pH, one could predict the degree of intestinal ischemia that had been induced by interruption of the blood supply and thus potentially the viability of the bowel.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1973
- Accession Number
- ADA064964
Entities
People
- Lester Williams Jr
Organizations
- Boston University