Effect of PGBx on Local Contractile Abnormalities Following Graded Reduction in Coronary Blood Flow.
Abstract
In the setting of acute myocardial ischemia, it is increasingly clear that a zone of myocardium exists which although demonstrating decreased contractile ability, maintains potential for contraction. In the present study, PGBx (1 mg i.v.) was administered to dogs following 1 hour of partial coronary occlusion. Within five minutes there was a marked improvement in contractile function in both the subepicardial and subendocardial layers of the ischemic zone. This affect was not seen in a group of control animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 26, 1979
- Accession Number
- ADA065514
Entities
People
- Hajime Yamazaki
- Monty M. Bodenheimer
- Richard H. Helfant