Cardio-Pulmonary Response to Shock.
Abstract
Pressure breathing and particularly PEEP were found to alter pulmonary metabolic activities. In animals treated with PEEP: there was release of a humoral agent which decreased contractility; plasminogen activator normally cleared by the lungs during spontaneous breathing was now secreted; there was a decreased ability to clear barbiturates and lactate; a selective red cell acidosis was induced (during lactate infusion); and systemic blood flow was redistributed. Metabolism was severely altered when a lung lobe was isolated and perfused from a support dog. A variety of negative inotropic agents were released which led to death of the support animal. These cardiac muscle studies were assisted by the development of a new, isolated papillary muscle chamber. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1978
- Accession Number
- ADA065672
Entities
People
- Herbert B. Hechtman
Organizations
- Harvard Medical School