Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins
Abstract
The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have demonstrated that (a) active immunization with a purified preparation of the polymyxin release form of Escherichia coli heat-labile enterotoxin yields protection against strains of this bacteria which produce this form of toxin; (b) the use of cimetidine renders the peroral route of immunization effective; and (c) peroral, but not parenteral, immunization affords extended protection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1979
- Accession Number
- ADA065776
Entities
People
- Frederick A. Klipstein
Organizations
- University of Rochester