Is Antibiotic/Steroid Post-Treatment Capable of Preventing Death in Escherichia Coli LD100 Shocked Baboons.
Abstract
Fourteen adult baboons (P. c. cynocephalus) were anesthetized and prepared aseptically for 2-hr infusions of 2.4 x 10 to 10th power E. coli organisms per kg body wt. Three groups were studied: Group I, E. coli alone; Group II, E. coli plus infusions of both gentamicine sulfate (GS) (18 mg/kg) and methylprednisolone sodium succinate (MPSS) (75 mg/kg); and Group III, E. coli plus GS (18 mg/kg). Animals were monitored during a 12-hr period and observed 7-21 days. Systemic hypotension occurred in all groups within 2 hr of E. coli infusion. Subsequent hypotension, hypoglycemia and death were prevented in all fully treated baboons (Group II) while all animals of Groups I and III died within 42 hr. In vitro studies utilizing GS with or without MPSS demonstrated the absence of organisms as early as 3 hr. Findings demonstrate the importance of maintenance infusions of both steroid and antibiotic in promoting survival in LD100 E. coli-induced shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 26, 1979
- Accession Number
- ADA065946
Entities
People
- B. K. Beller-todd
- D. J. Flournoy
- J. J. Coalson
- Lerner B. Hinshaw
- Linda T. Archer
Organizations
- University of Oklahoma Health Sciences Center